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The various kinds of cells that can give rise to NETs are present in endocrine glands and are also diffusely distributed throughout the body, most commonly Kulchitsky cells or similar enterochromaffin-like cells, that are relatively more common in the gastrointestinal and pulmonary systems. NETs can arise in many different areas of the body, and are most often located in the intestine, pancreas or the lungs. Traditionally, neuroendocrine tumors have been classified by their anatomic site of origin. Placing a given tumor into one of these categories depends on well-defined histological features: size, lymphovascular invasion, mitotic count, Ki-67 labelling index, invasion of adjacent organs, presence of metastases and whether they produce hormones. poorly differentiated (high grade) neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas.Īdditionally, the WHO scheme recognizes mixed tumors with both neuroendocrine and epithelial carcinoma features, such as goblet cell cancer, a rare gastrointestinal tract tumor.well-differentiated (low grade) neuroendocrine carcinomas with low-grade malignant behavior.well-differentiated neuroendocrine tumours, further subdivided into tumors with benign and those with uncertain behavior.The World Health Organization (WHO) classification scheme places neuroendocrine tumors into three main categories, which emphasize the tumor grade rather than the anatomical origin: 5.3.1 Gastrointestinal neuroendocrine tumors.4.3.2 Argentaffin and hormone secretion.
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